Shaiman plays the piano. Jordan Ballard, Margaret Cho, Barrett Foa, J.B. Ghuman, John Hill, Andy Richter, Maya Rudolph, Rashad Naylor, Nicole Parker star as 'California Gays and The People That Love Them'. John C Reilly as a Prop 8 leader, and Alison Janney as his wife. Kathy Najimy as his second wife. Jenifer Lewis as a riffing Prop 8'er. Craig Robinson as a preacher. Rashida Jones, Lake Bell, Sarah Chalke as Scary Catholic School Girls from Hell. Katharine "Kooks" Leonard, Seth Morris, Denise "Esi!" Piane, Lucian Piane, Richard Read, Seth Redford, Quinton Strack, and Tate Taylor as The Frightened Villagers.
Jack Black stars as Jesus Christ, and Neil Patrick Harris is billed as 'A Very Smart Fellow'.